Established on March 1, 1994, Quezon City University, formerly known as the Quezon City Polytechnic University was created to undertake skilled workers' training in response to the manpower requirement by industry and business establishments within the city.

The QCP established its reputation among local government units as a show window and model technology-based institution, paving the way for its recognition by the Technical Education Skills and Development Authority (TESDA) and developing a strong alliance with the Japanese International Cooperation Agency (JICA). On August 20, 1997, the Polytechnic was enhanced into a University through City Council Ordinance No. SP-544, S-97.

Starting 2005-2006, through the leadership of former Quezon City Mayor Feliciano “Sonny” Belmonte, the University has started offering degree programs: BS in Entrepreneurial Management, BS in Information Technology, and BS in Industrial Engineering.

In July 2019, the SP-2812 s.2019 or the “Ordinance converting the Quezon City Polytechnic University to Quezon City University and enhancing its charter” was fully implemented. Subsequently, Ordinance No. SP-2998, S. 2021, also known as “Quezon City University Charter of 2021” was signed and instigated, strengthening the University’s mandate.

For 27 years since its establishment, QCU has evolved significantly – from being a technical education provider to a local government university, Institutionally Recognized by the Commission on Higher Education (CHED) last June 17, 2021. QCU now offers degree programs in Bachelor in Accountancy, Bachelor in Entrepreneurship, Bachelor in Electronics Engineering, Bachelor in Industrial Engineering, and Bachelor in Information Technology. Soon, QCU will cater to more talented and deserving students by providing relevant undergraduate and graduate programs that meet domestic and global markets' demands.